abstract：:Lipopolysaccharide (LPS) can activate endothelial cells and induce inflammatory injury. Toll-like receptor-4 (TLR-4) is integrally involved in LPS signaling and has a requisite role in the activation of nuclear factor (NF)-κB. A number of studies have demonstrated the cytoprotective action of perfluorocarbon (PFC) bot...

journal_title：Inflammation

authors： Xu S,Wang P,Wei K,Liu F,Liang Z,Zhao X,Li A,Chen L

更新日期：2013-04-01 00:00:00

abstract：:The nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) is commonly used to study free radicals. Due to its free radical trapping properties, DMPO is thought to reduce free radial-mediated oxidative damage and other related cellular responses. The purpose of this study was to assess the effect of DMPO on lipopol...

journal_title：Inflammation

authors： Zhai Z,Gomez-Mejiba SE,Ramirez DC

更新日期：2013-04-01 00:00:00

abstract：:Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8(+) T lymphocyte...

journal_title：Inflammation

authors： Ahmadabadi BN,Hassanshahi G,Khoramdelazad H,Mirzaei V,Sajadi SM,Hajghani M,Khodadadi H,Pourali R,Arababadi MK,Kennedy D

更新日期：2013-02-01 00:00:00

abstract：:Low-grade chronic systemic inflammation is often associated with chronic non-communicable diseases, and its most frequently used marker, the C-reactive protein (CRP), has become an identifier of such diseases as well as an independent predictor for cardiovascular disorders and mortality. CRP is produced in response to...

journal_title：Inflammation

authors： Moreto F,de Oliveira EP,Manda RM,Torezan GA,Teixeira O,Michelin E,Burini RC

更新日期：2013-02-01 00:00:00

abstract：:We aimed to compare serum levels of the inflammatory mediators including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD), obstructive sleep apnea syndrome (OSAS), and their coexistence called overlap syndrome (OVS). In ad...

journal_title：Inflammation

authors： Nural S,Günay E,Halici B,Celik S,Ünlü M

更新日期：2013-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study w...

journal_title：Inflammation

authors： Demir T,Turkbeyler I,Kaplan DS,Pehlivan Y,Orkmez M,Tutar E,Taysi S,Kisacik B,Onat AM,Bagcı C

更新日期：2013-02-01 00:00:00

abstract：:Recent data have demonstrated the importance of IL-18 in the induction and perpetuation of chronic inflammation in experimental arthritis. The aim of the present study was to elucidate whether IL-18 has any indirect effects on osteoclastogenesis by regulating the production of molecules from fibroblast-like synoviocyt...

journal_title：Inflammation

authors： Zhang W,Cong XL,Qin YH,He ZW,He DY,Dai SM

更新日期：2013-02-01 00:00:00

abstract：:Different studies have shown the regulatory effects of vitamin D(3) on the immune system and bone metabolism. Regarding the effects of vitamin D on immune cells and the importance of cytokines on bone metabolism, we assessed the association between serum levels of interleukin (IL)-6, IL-10, IL-12, IL-17 and IFN-γ cyto...

journal_title：Inflammation

authors： Jamali Z,Arababadi MK,Asadikaram G

更新日期：2013-02-01 00:00:00

abstract：:The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung ...

journal_title：Inflammation

authors： Komatsu Y,Yamamoto H,Tsushima K,Furuya S,Yoshikawa S,Yasuo M,Kubo K,Yamazaki Y,Hasegawa J,Eguchi T,Kondo R,Yoshida K,Koizumi T

更新日期：2012-12-01 00:00:00

abstract：:The present study was performed to explore the effect of aqueous extract of Aloe vera on behavioural parameters of pain. Pain assessment was performed by the tail-flick and formalin tests. A. vera (100 mg/kg, per oral (p.o.)) produced an insignificant decrease in the pain response in the tail-flick and formalin tests....

journal_title：Inflammation

authors： Rathor N,Mehta AK,Sharma AK,Mediratta PK,Sharma KK

更新日期：2012-12-01 00:00:00

abstract：:In our study, we explored the bidirectional communication via soluble factors between bone cells and endotoxin-stimulated splenic lymphocytes in an in vitro coculture model that mimics the inflammatory environment. Both the ability of lymphocytes to affect differentiation and immune properties of bone cells, osteoblas...

journal_title：Inflammation

authors： Cvija H,Kovacic N,Katavic V,Ivcevic S,Aguila HL,Marusic A,Grcevic D

更新日期：2012-10-01 00:00:00

abstract：:Strong anti-inflammatory activity has been found in Laminaria japonica dichloromethane fraction (LDF); however, the molecular mechanisms underlying its anti-inflammatory activity are not reported. Our results indicated that LDF inhibited LPS-induced nitric oxide and prostaglandin E(2) production in a dose-dependent ma...

journal_title：Inflammation

authors： Lee JY,Lee MS,Choi JW,Shin TS,Woo HC,Kim HR

更新日期：2012-10-01 00:00:00

abstract：:Type I allergy is characterized by the release of granule-associated mediators, lipid-derived substances, cytokines, and chemokines by activated mast cells. To evaluate the anti-allergic effects of macelignan isolated from Myristica fragrans Houtt., we determined its ability to inhibit calcium (Ca(2+)) influx, degranu...

journal_title：Inflammation

authors： Han YS,Kim MS,Hwang JK

更新日期：2012-10-01 00:00:00

abstract：:Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...

journal_title：Inflammation

authors： Hu W,Yu Q,Zhang J,Liu D

更新日期：2012-08-01 00:00:00

abstract：:Whether lipopolysaccharide (LPS) can promote vasa vasorum (VV) proliferation for atherosclerosis in vivo is unclear. Eighteen rabbits with atherosclerosis were randomly assigned into one of three groups of six. Group A received biweekly injections of 10 mL saline after 2 weeks of balloon injury. Groups B and C receive...

journal_title：Inflammation

authors： Tian J,Hu S,Han X,Dong N,Yu H,Sun Y,Yu B

更新日期：2012-08-01 00:00:00

abstract：:This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...

journal_title：Inflammation

authors： Qin HB,Xu B,Mei JJ,Li D,Liu JJ,Zhao DY,Liu F

更新日期：2012-08-01 00:00:00

abstract：:The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH ...

journal_title：Inflammation

authors： Zheng GH,Xiong SQ,Mei LJ,Chen HY,Wang T,Chu JF

更新日期：2012-08-01 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) with exogenous cassette DNA containing the methicillin-resistant gene mecA (SCCmec) poses a problem as a drug-resistant bacterium responsible for hospital- and community-acquired infections. The frequency of MRSA detection has recently been increasing rapidly in Japan...

journal_title：Inflammation

authors： Nihonyanagi S,Kanoh Y,Okada K,Uozumi T,Kazuyama Y,Yamaguchi T,Nakazaki N,Sakurai K,Hirata Y,Munekata S,Ohtani S,Takemoto T,Bandoh Y,Akahoshi T

更新日期：2012-06-01 00:00:00

abstract：:Praeruptorin C, D, and E (PC, PD, and PE) are three pyranocoumarins isolated from the dried root of Peucedanum praeruptorum Dunn of Umbelliferae. In the present study, we investigated the anti-inflammatory effect of these compounds in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Pyranocoumarins signi...

journal_title：Inflammation

authors： Yu PJ,Jin H,Zhang JY,Wang GF,Li JR,Zhu ZG,Tian YX,Wu SY,Xu W,Zhang JJ,Wu SG

更新日期：2012-06-01 00:00:00

abstract：:The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was...

journal_title：Inflammation

authors： Xu Y,Zhang W,Zhang P,Xiao L,Wang A,Sirois P,Li K

更新日期：2012-06-01 00:00:00

abstract：:Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to i...

journal_title：Inflammation

authors： Li Y,Yan J,Xu W,Wang H,Xia Y

更新日期：2012-06-01 00:00:00

abstract：:C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive pow...

journal_title：Inflammation

authors： Melbye H,Amundsen K,Brox J,Eggen AE

更新日期：2012-06-01 00:00:00

abstract：:We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cycloo...

journal_title：Inflammation

authors： Wu YQ,Chen XS,Chai JB

更新日期：2012-06-01 00:00:00

abstract：:Alveolar macrophages (AMs) can initiate lung inflammation by producing pro-inflammatory cytokines and chemokines, but they participate actively in the prevention of inflammation during acute lung injury (ALI). Heme oxygenase-1 (HO-1) is mainly expressed in AMs and has anti-inflammatory properties in ALI, but the anti-...

journal_title：Inflammation

authors： Hualin C,Wenli X,Dapeng L,Xijing L,Xiuhua P,Qingfeng P

更新日期：2012-06-01 00:00:00

abstract：:The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed that single-nucleotide po...

journal_title：Inflammation

authors： Arababadi MK,Reza Mirzaei M,Ali Sajadi SM,Hassanshahi G,Ahmadabadi BN,Salehabadi VA,Derakhshan R,Kennedy D

更新日期：2012-06-01 00:00:00

abstract：:Asthma is a complex disease linked to various pathophysiological events, including proteinase activity. In this study, we examined whether a Diospyros blancoi methanolic extract (DBE) exerts protective effects on allergic asthma in a murine asthma model. To investigate the specific role of DBE, we employed a murine mo...

journal_title：Inflammation

authors： Lee KY,Jung JY,Lee MY,Jung D,Cho ES,Son HY

更新日期：2012-04-01 00:00:00

abstract：:The prevalence of CD4+CD25(high) regulatory T cells (Tregs) in patients with acute-on-chronic liver failure (AoCLF) who received plasma exchange (PE) and/or medical treatment was investigated. One hundred five patients with AoCLF in two groups (PE plus routine-care, n = 48 and routine-care, n = 57) were enrolled in ou...

journal_title：Inflammation

authors： Mao WL,Lou YF,Ye B,Lin S,Chen YM,Chen Y

更新日期：2012-04-01 00:00:00

abstract：:The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...

journal_title：Inflammation

authors： Gunjaca I,Zunic J,Gunjaca M,Kovac Z

更新日期：2012-04-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the predominant cause of irreversible blindness in the elderly population. Despite intensive basic and clinical research, its pathogenesis remains unclear. However, evidence suggests that immunological and inflammatory factors contribute to the pathogenesis of AMD. A newly ide...

journal_title：Inflammation

authors： Liu XC,Liu XF,Jian CX,Li CJ,He SZ

更新日期：2012-04-01 00:00:00

abstract：:Parthenolide, a naturally occurring sesquiterpene lactone derived from feverfew (Tanacetum parthenium), exhibits exceptional anti-cancer and anti-inflammatory properties, making it a prominent candidate for further studies and drug development. In this review, we briefly investigate molecular events and cell-specific ...

journal_title：Inflammation

authors： Mathema VB,Koh YS,Thakuri BC,Sillanpää M

更新日期：2012-04-01 00:00:00

abstract：:Release and activation of pro-inflammatory mediators are among the most important induced factors that are involved in the scorpion envenomation pathogenesis. Inflammatory response and lung reactivity were studied in mice following subcutaneous injection with Androctonus australis hector (Aah) venom. Venom immunodetec...

journal_title：Inflammation

authors： Adi-Bessalem S,Mendil A,Hammoudi-Triki D,Laraba-Djebari F

更新日期：2012-04-01 00:00:00

abstract：:The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...

journal_title：Inflammation

authors： Banerjee A,Mondal NK,Das D,Ray MR

更新日期：2012-04-01 00:00:00

abstract：:Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...

journal_title：Inflammation

authors： Wang Y,Zhang F,Yang W,Xue S

更新日期：2012-02-01 00:00:00

abstract：:Tumour necrosis factor-α (TNFα) and polymorphonuclear neutrophils play key and interrelated roles in the inflammatory response against infectious agents. However, these entities can mediate significant tissue damage if their biological activity becomes deregulated. We have previously shown that canine hyperimmune froz...

journal_title：Inflammation

authors： Essien BE,Kotiw M

更新日期：2012-02-01 00:00:00

abstract：:The liver is an immunocompetent organ that plays a key role in the immune response to infections, and the development of hepatic immune function during early postnatal stages has not been thoroughly characterized. This study analyzed the constitutive expression of complement factors, namely C3 and C9, and pattern reco...

journal_title：Inflammation

authors： Le Rouzic V,Corona J,Zhou H

更新日期：2011-12-01 00:00:00

abstract：:The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabolite of kakkalide produced by intestinal microflora, against carrageenan-induced inflammation in air pouches on the backs of mice and in lipopolysaccharide (LPS)-stimulated peritoneal mac...

journal_title：Inflammation

authors： Min SW,Park YJ,Kim DH

更新日期：2011-10-01 00:00:00

abstract：:There is substantial evidence suggesting that the Ras inhibitor farnesylthiosalicylic acid (FTS) may modulate various aspects of immune function and inflammation in addition to its well known anti-cancer activity. In this regard, we have recently shown that FTS suppresses T lymphocyte-mediated immune responses. Mast c...

journal_title：Inflammation

authors： Mor A,Ben-Moshe O,Mekori YA,Kloog Y

更新日期：2011-10-01 00:00:00

abstract：:Our study showed that S-methylisothiourea (SMT) had anti-inflammatory effects in treating herpes simplex encephalitis in mice, and SMT also induced apoptosis of herpes simplex virus (HSV-1)-infected microglial cells. Both animal and cell models were employed in this study. Both models included the following five group...

journal_title：Inflammation

authors： Guo YJ,Li W,Li XF,Zhao L,Zhang SL,Zhou Y,Dong JH,Mei YW

更新日期：2011-10-01 00:00:00

abstract：:In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, t...

journal_title：Inflammation

authors： Sabina EP,Nagar S,Rasool M

更新日期：2011-06-01 00:00:00

abstract：:Migration inhibitory factor (MIF) is associated with multiple organ dysfunction syndrome (MODS) in patients with systemic inflammatory response syndrome (SIRS). Our purposes were to determine the serum MIF, cortisol, and tumor narcosis factor-α (TNF-α) and to investigate the influences of the balance between the level...

journal_title：Inflammation

authors： Hayakawa M,Katabami K,Wada T,Minami Y,Sugano M,Shimojima H,Kubota N,Uegaki S,Sawamura A,Gando S

更新日期：2011-06-01 00:00:00